Article
The -319C/+49G/CT60G haplotype of CTLA-4 gene confers susceptibility to rheumatoid arthritis in Mexican population.
Cell biochemistry and biophysics - 1 Jan 2013
Torres-Carrillo Norma, Ontiveros-Mercado Heriberto, Torres-Carrillo Nora Magdalena, Parra-Rojas Isela, Rangel-Villalobos Héctor, Ramírez-Dueñas María Guadalupe, Gutiérrez-Ureña Sergio Ramón, Valle Yeminia, Muñoz-Valle José Francisco
Abstract excerpt
Several single nucleotide polymorphisms (SNPs) within the CTLA-4 gene and elevated serum levels of soluble CTLA-4 (sCTLA-4) have been associated with autoimmunity including rheumatoid arthritis (RA). In this case-control study, we evaluated the relationship between the -319C/T (rs5742909) and CT60 G/A (rs3087243) SNPs and sCTLA-4 levels in 200 RA patients and 200 control subjects (CS) from Western Mexico. Both...
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