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Article

Factor VIII gene (F8) mutations as predictors of outcome in immune tolerance induction of hemophilia A patients with high-responding inhibitors.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2009

Coppola A, Margaglione M, Santagostino E, Rocino A, Grandone E, Mannucci P M, Di Minno G

Abstract excerpt

BACKGROUND: Immune tolerance induction (ITI) is the only therapeutic approach that can eradicate factor VIII (FVIII) inhibitors in patients with hemophilia A. Predictors of ITI outcome are still debated, and the role of F8 gene mutations in this is not well established. OBJECTIVES: To investigate the relationship between F8 genotype and ITI outcome in patients with severe hemophilia A and high-responding...

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Source

Identifiers

PMID: 19740093
DOI: 10.1111/j.1538-7836.2009.03615.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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