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Article

Prediction of factor VIII inhibitor development in the SIPPET cohort by mutational analysis and factor VIII antigen measurement.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2018

Spena S, Garagiola I, Cannavò A, Mortarino M, Mannucci P M, Rosendaal F R, Peyvandi F

Abstract excerpt

Essentials A residual factor VIII synthesis is likely to be protective towards inhibitor (INH) development. Mutation type-inhibitor risk association was explored in 231 patients with severe hemophilia A. A 2-fold increase in INH development for in silico null vs. non-null mutations was found. A 3.5-fold increase in INH risk for antigen negative vs. antigen positive mutations was found. SUMMARY: Background The...

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PMID: 29399993
DOI: 10.1111/jth.13961

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