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Article

Early immune tolerance induction is a unique predictor of favorable outcomes in hemophilia A children with intron 22 inversion and high-responding inhibitors.

Thrombosis research - 1 Jun 2023

Sun Jie, Li Zekun, Li Gang, Liu Guoqing, Yao Wanru, Zhen Yingzi, Chen Zhenping, Wu Runhui

Abstract excerpt

BACKGROUND: The predictors of immune tolerance induction (ITI) outcomes in hemophilia A (HA) patients with the same F8 genetic background have not yet been evaluated, although the F8 genotype is strongly associated with ITI response. This study aims to explore the predictors of ITI outcomes in the same F8 genetic background by focusing on intron 22 inversion (Inv22) patients with high-responding inhibitors....

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PMID: 37121012
DOI: 10.1016/j.thromres.2023.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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