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Article

F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis.

Blood - 22 Mar 2012

Gouw Samantha C, van den Berg H Marijke, Oldenburg Johannes, Astermark Jan, de Groot Philip G, Margaglione Maurizio, Thompson Arthur R, van Heerde Waander, Boekhorst Jorien, Miller Connie H, le Cessie Saskia, van der Bom Johanna G

Abstract excerpt

This systematic review was designed to provide more precise effect estimates of inhibitor development for the various types of F8 gene mutations in patients with severe hemophilia A. The primary outcome was inhibitor development and the secondary outcome was high-titer-inhibitor development. A sy...

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Identifiers

PMID: 22282501
DOI: 10.1182/blood-2011-09-379453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22282501-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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