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Article

Immune tolerance induction with recombinant factor VIII in hemophilia A patients with high responding inhibitors.

Haematologica - 1 Apr 2006

Rocino Angiola, Santagostino Elena, Mancuso Maria Elisa, Mannucci Pier Mannuccio

Abstract excerpt

Immune tolerance induction (ITI) eradicates inhibitors in patients with hemophilia A. This study was designed to investigate the success rate of ITI in high-responding inhibitor patients with severe hemophilia A using recombinant factor VIII (rFVIII). Twenty-six patients received different ITI regimens until a normal recovery (>66%) and half-life (>6 h) of infused FVIII was achieved. In order to maximize the...

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PMID: 16585022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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