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Article

p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases.

Cancer research - 1 May 2009

Yokobori Takehiko, Mimori Koshi, Iwatsuki Masaaki, Ishii Hideshi, Onoyama Ichiro, Fukagawa Takeo, Kuwano Hiroyuki, Nakayama Keiichi I, Mori Masaki

Abstract excerpt

A molecular target associated with the progression of gastric cancer has not yet been uncovered. FBXW7 is a tumor suppressor gene transcriptionally controlled by p53 that plays a role in the regulation of cell cycle exit and reentry via c-Myc degradation. Few studies have addressed the clinical significance of FBXW7 expression in gastric cancer. Therefore, we examined FBXW7 mRNA expression to determine its...

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Identifiers

PMID: 19366810
DOI: 10.1158/0008-5472.CAN-08-2846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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