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Article

Evaluation of Fbxw7 expression and its correlation with the expression of c‐Myc, cyclin E and p53 in human hepatocellular carcinoma

20 Mar 2012

Abstract excerpt

AIM: F-box and WD repeat domain-containing 7 (Fbxw7) is a cell cycle regulatory gene that targets for ubiquitination and proteasomal degradation various cell cycle regulators such as c-Myc and cyclin E. Defects in the Fbxw7 gene that lead to cell cycle re-entry and expedite the G1-S transition is thought to be one of the causes of cancer development. However, its expression and clinical importance for...

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PMID: 22548670
DOI: 10.1111/j.1872-034x.2012.01005.x

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