Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancers

29 Mar 2023

Abstract excerpt

Background: FBXW7 is recognized as a critical tumor suppressor gene and a component of the ubiquitin-proteasome system, mediating the degradation of multiple oncogenic proteins, including c-MYC, Cyclin E, c-Jun, Notch, p53. Around 16% of colorectal cancer (CRC) patients carried FBXW7 somatic mutations, while a comprehensive characterization of FBXW7 somatic mutations in CRC is still lacking. Methods: Colorectal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Connective tissue disorders research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37064111
DOI: 10.3389/fonc.2023.1154432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancersPMID 37064111Read ↗

Clinical Significance of Fbxw7 Tumor Suppressor Gene Mutations and Expression in Human Colorectal Cancer: A Systemic Review and Meta-analysisSemantic proximity Read ↗

Clinical significance of FBXW7 tumor suppressor gene mutations and expression in human colorectal cancer: a systemic review and meta-analysis.Semantic proximity Read ↗

Prognostic value of FBXW7 tumor suppressor gene expression and mutations in patients with colorectal cancer: A meta-analysis.Semantic proximity Read ↗

Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligaseSemantic proximity Read ↗

FBXW7 mutation analysis and its correlation with clinicopathological features and prognosis in colorectal cancer patients.Semantic proximity Read ↗

Alteration of FBXW7 is Associated with Worse Survival in Patients Undergoing Resection of Colorectal Liver Metastases.Semantic proximity Read ↗

Clinical significance of FBXW7 loss of function in human cancersSemantic proximity Read ↗

Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations.Semantic proximity Read ↗

Recent insight into the role of FBXW7 as a tumor suppressor.Semantic proximity Read ↗

FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective StrategiesSemantic proximity Read ↗

FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinomaSemantic proximity Read ↗

Comprehensive Study of Human FBXW7 Deleterious nsSNP's Functional Inference and Susceptibility to Gynaecological CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.