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Article

FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.

Cancer science - 1 Oct 2016

Kitade Shoko, Onoyama Ichiro, Kobayashi Hiroaki, Yagi Hiroshi, Yoshida Sachiko, Kato Masaya, Tsunematsu Ryosuke, Asanoma Kazuo, Sonoda Kenzo, Wake Norio, Hata Kenichiro, Nakayama Keiichi I, Kato Kiyoko

Abstract excerpt

FBXW7 is a ubiquitin ligase that mediates ubiquitylation of oncoproteins, such as c-Myc, cyclin E, Notch and c-Jun. FBXW7 is a known tumor-suppressor gene, and mutations in FBXW7 have been reported in various human malignancies. In this study, we examined the sequences of the FBXW7 and p53 genes in 57 ovarian cancer clinical samples. Interestingly, we found no FBXW7 mutations associated with amino acid changes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27486687
DOI: 10.1111/cas.13026
PMCID: PMC5084658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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