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Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells

5 Oct 2016

Abstract excerpt

The transcription factor c-Myb is essential for the proliferation of hematopoietic cells and has been implicated in the development of leukemia and other human cancers. Pharmacologic inhibition of Myb is therefore emerging as a potential therapeutic strategy for these diseases. By using a Myb reporter cell line, we have identified plumbagin and several naphthoquinones as potent low-molecular weight Myb...

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PMID: 27707899
DOI: 10.1158/1535-7163.mct-16-0185

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