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Article

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

30 May 2013

Abstract excerpt

Regulation of metabolic pathways plays an important role in controlling cell growth, proliferation, and survival. TIGAR acts as a fructose-2,6-bisphosphatase, potentially promoting the pentose phosphate pathway to produce NADPH for antioxidant function and ribose-5-phosphate for nucleotide synthesis. The functions of TIGAR were dispensable for normal growth and development in mice but played a key role in...

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Identifiers

PMID: 23726973
DOI: 10.1016/j.devcel.2013.05.001

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