Article
Notch-Dependent Pituitary SOX2(+) Stem Cells Exhibit a Timed Functional Extinction in Regulation of the Postnatal Gland.
Stem cell reports - 8 Dec 2015
Zhu Xiaoyan, Tollkuhn Jessica, Taylor Havilah, Rosenfeld Michael G
Abstract excerpt
Although SOX2(+) stem cells are present in the postnatal pituitary gland, how they are regulated molecularly and whether they are required for pituitary functions remain unresolved questions. Using a conditional knockout animal model, here we demonstrate that ablation of the canonical Notch signaling in the embryonic pituitary gland leads to progressive depletion of the SOX2(+) stem cells and hypoplastic gland....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.