Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

Development (Cambridge, England) - 1 Jan 2004

Palma Veronica, Ruiz i Altaba Ariel

Abstract excerpt

Stem cells are crucial for normal development and homeostasis, and their misbehavior may be related to the origin of cancer. Progress in these areas has been difficult because the mechanisms regulating stem cell lineages are not well understood. Here, we have investigated the role of the SHH-GLI pathway in the developing mouse neocortex. The results show that SHH signaling endogenously regulates the number of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epidermal Growth Factor
Share to Hedgehog Proteins
Share to Kruppel-Like Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

Share to Neocortex

Share to Stem Cells

Share to Zinc Finger Protein Gli2

Share to Zinc Finger Protein Gli3

Source

Identifiers

PMID: 14681189
DOI: 10.1242/dev.00930

Genes

SHH
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.PMID 14681189Read ↗

Hedgehog signaling is involved in development of the neocortex.Semantic proximity Read ↗

Hedgehog Signaling in Cortical DevelopmentSemantic proximity Read ↗

The neocortical progenitor specification program is established through combined modulation of SHH and FGF signalingSemantic proximity Read ↗

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain developmentSemantic proximity Read ↗

Gli1 Induces G2/M Arrest and Apoptosis in Hippocampal but Not Tumor-Derived Neural Stem CellsSemantic proximity Read ↗

The sonic hedgehog-GLI1 signaling pathway in brain tumor developmentSemantic proximity Read ↗

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh.Semantic proximity Read ↗

Signal requirement for cortical potential of transplantable human neuroepithelial stem cellsSemantic proximity Read ↗

Hedgehog signaling in cancer stem cells: a focus on hematological cancersSemantic proximity Read ↗

Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain.Semantic proximity Read ↗

Neural stem cell engineering: directed differentiation of adult and embryonic stem cells into neurons.Semantic proximity Read ↗

Unraveling the transcriptional networks that drive oligodendrocyte fate specification in Sonic hedgehog-responsive neocortical progenitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.