Article
The glycerol-3-phosphate permease GlpT is the only fosfomycin transporter in Pseudomonas aeruginosa.
Journal of bacteriology - 1 Nov 2009
Castañeda-García Alfredo, Rodríguez-Rojas Alexandro, Guelfo Javier R, Blázquez Jesús
Abstract excerpt
Fosfomycin is transported into Escherichia coli via both glycerol-3-phosphate (GlpT) and a hexose phosphate transporter (UhpT). Consequently, the inactivation of either glpT or uhpT confers increased fosfomycin resistance in this species. The inactivation of other genes, including ptsI and cyaA, also confers significant fosfomycin resistance. It has been assumed that identical mechanisms are responsible for...
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