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Article

Molecular insights into fosfomycin resistance in Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 May 2017

Ballestero-Téllez M, Docobo-Pérez F, Portillo-Calderón I, Rodríguez-Martínez J M, Racero L, Ramos-Guelfo M S, Blázquez J, Rodríguez-Baño J, Pascual A

Abstract excerpt

Objectives: Fosfomycin activity in Escherichia coli depends on several genes of unknown importance for fosfomycin resistance. The objective was to characterize the role of uhpT , glpT , cyaA and ptsI genes in fosfomycin resistance in E. coli. Methods: WT E. coli BW25113 and null mutants, Δ uhpT , Δ glpT , Δ cyaA , Δ ptsI , Δ glpT-uhpT , Δ glpT-cyaA , Δ glpT-ptsI , Δ uhpT-cyaA , Δ uhpT-ptsI and Δ ptsI-cyaA , were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28093485
DOI: 10.1093/jac/dkw573

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