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hptA Mutation May Mediate Fosfomycin Resistance in Methicillin-Resistant Staphylococcus aureus Clinical Isolates.

Microbial drug resistance (Larchmont, N.Y.) - 1 Nov 2023

Wang Jue, Xu Xiaogang, Zhao Xiaoyu, Xu Su, Wang Minggui

Abstract excerpt

Fosfomycin can be used alone or in combination to treat methicillin-resistant Staphylococcus aureus (MRSA) infection. However, fosfomycin resistance has been observed in MRSA. In S. aureus, fosfomycin resistance is mediated by the fosfomycin-modifying enzyme FosB, or mutations in the target enzyme MurA. Mutations in the chromosomal glpT and uhpT genes, which encode fosfomycin transporters, also result in...

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PMID: 37603296
DOI: 10.1089/mdr.2022.0173

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