Association within a family of a balanced autosomal translocation with major mental illness.

doi:10.1016/0140-6736(90)91520-k

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Association within a family of a balanced autosomal translocation with major mental illness.

Lancet (London, England) - 7 Jul 1990

St Clair D, Blackwood D, Muir W, Carothers A, Walker M, Spowart G, Gosden C, Evans H J

Abstract excerpt

282 pedigrees in the MRC Cytogenetics Registry, Edinburgh, with familial autosomal anomalies were examined for the presence of associated mental illness. In one large pedigree there were 23 cases of mental and/or behavioural disorders meeting Research Diagnostic Criteria. 34 of the 77 family memb...

Topics

Adolescent
Adult
Child
Chromosome Aberrations
Chromosome Disorders
Chromosome Mapping
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 11
Disease Susceptibility
Female
Genetic Linkage
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lod Score

Male

Mental Disorders

Odds Ratio

Pedigree

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1973210
DOI: 10.1016/0140-6736(90)91520-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1973210-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association within a family of a balanced autosomal translocation with major mental illness.PMID 1973210Read ↗

An allelic association study of two polymorphic markers in close proximity to a balanced translocation t(1:11) that co-segregates with mental illness.Semantic proximity Read ↗

Recombination patterns around the breakpoints of a balanced 1;11 autosomal translocation associated with major mental illness.Semantic proximity Read ↗

Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.Semantic proximity Read ↗

Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/functionSemantic proximity Read ↗

A Genetic Mechanism Implicates Chromosome 11 in Schizophrenia and Bipolar DiseasesSemantic proximity Read ↗

A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3.Semantic proximity Read ↗

A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes.Semantic proximity Read ↗

Initial report of a genome search for the affective disorder predisposition gene in the old order Amish pedigrees: chromosomes 1 and 11.Semantic proximity Read ↗

A high predisposition to depression and anxiety in mothers and other matrilineal relatives of children with presumed maternally inherited mitochondrial disorders.Semantic proximity Read ↗

Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.Semantic proximity Read ↗

An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis.Semantic proximity Read ↗

Novel transcribed sequences neighbouring a translocation breakpoint associated with schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.