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A Genetic Mechanism Implicates Chromosome 11 in Schizophrenia and Bipolar Diseases

1 Aug 2004

Abstract excerpt

The causes of schizophrenia and bipolar human psychiatric disorders are unknown. A novel somatic cell genetic model postulated nonrandom segregation of "Watson" vs. "Crick" DNA chains of both copies of a chromosome to specific daughter cells. Such an oriented asymmetric cell division causes development of healthy, functionally nonequivalent brain hemispheres. Genetic translocations of the chromosome may cause...

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PMID: 15342521
DOI: 10.1534/genetics.104.028217

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