Article
Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.
American journal of human genetics - 1 Aug 2001
Blackwood D H, Fordyce A, Walker M T, St Clair D M, Porteous D J, Muir W J
Abstract excerpt
A family with a (1;11)(q42;q14.3) translocation significantly linked to a clinical phenotype that includes schizophrenia and affective disorders is described. This translocation generates a LOD score of 3.6 when the disease phenotype is restricted to schizophrenia, of 4.5 when the disease phenotype is restricted to affective disorders, of 7.1 when relatives with recurrent major depression, with bipolar disorder,...
Topics
- Adolescent
- Adult
- Brain
- Chromosome Breakage
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 11
- Event-Related Potentials, P300
- Female
- Gene Frequency
- Genotype
- Humans
- Intelligence Tests