Article
ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.
Cancer research - 1 Mar 2012
Shigechi Tomoko, Tomida Junya, Sato Koichi, Kobayashi Masahiko, Eykelenboom John K, Pessina Fabio, Zhang Yanbin, Uchida Emi, Ishiai Masamichi, Lowndes Noel F, Yamamoto Kenichi, Kurumizaka Hitoshi, Maehara Yoshihiko, Takata Minoru
Abstract excerpt
ATR kinase activates the S-phase checkpoint when replication forks stall at sites of DNA damage. This event also causes phosphorylation of the Fanconi anemia (FA) protein FANCI, triggering its monoubiquitination of the key DNA repair factor FANCD2 by the FA core E3 ligase complex, thereby promoting this central pathway of DNA repair which permits replication to be restarted. However, the interplay between ATR and...
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