Article
DR*W201/P65 tetramer visualization of epitope-specific CD4 T-cell during M. tuberculosis infection and its resting memory pool after BCG vaccination.
PloS one - 4 Sept 2009
Wei Huiyong, Wang Richard, Yuan Zhuqing, Chen Crystal Y, Huang Dan, Halliday Lisa, Zhong Weihua, Zeng Gucheng, Shen Yun, Shen Ling, Wang Yunqi, Chen Zheng W
Abstract excerpt
BACKGROUND: In vivo kinetics and frequencies of epitope-specific CD4 T cells in lymphoid compartments during M. tuberculosis infection and their resting memory pool after BCG vaccination remain unknown. METHODOLOGY/FINDINGS: Macaque DR*W201 tetramer loaded with Ag85B peptide 65 was developed to directly measure epitope-specific CD4 T cells in blood and tissues form macaques after M. tuberculosis infection or BCG...
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