Article

Tandem Requirement for Full Renal D <sub>1</sub> R and D <sub>5</sub> R Activity

2019-08-15

Abstract excerpt

<h4>ABSTRACT</h4> The peripheral dopaminergic system promotes the maintenance of blood pressure homeostasis by engendering natriuresis, mainly through the renal D 1 R and D 5 R receptors. This effect is most apparent under conditions of moderate body sodium excess. Human and rodent renal proximal tubules express both receptors, which share common structural features and pharmacological profiles. Genetic ablatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eeed511c-84c8-566e-a618-e6e6193ff6f4
DOI: 10.1101/736611

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tandem Requirement for Full Renal D <sub>1</sub> R and D <sub>5</sub> R ActivityDOI 10.1101/736611Read

Functional genomics of the dopaminergic system in hypertensionSemantic proximity Read

DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATIONSemantic proximity Read

Diminished nuclear-localized β-adrenergic signaling activates YAP to promote kidney fibrosis in diabetic nephropathySemantic proximity Read

C-terminal di-leucine motif of dopamine D₁ receptor plays an important role in its plasma membrane trafficking.Semantic proximity Read

Renin-Angiotensin-Aldosterone System Antagonism and Polycystic Kidney Disease Progression.Semantic proximity Read

Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension.Semantic proximity Read

Renal dopaminergic defect in C57Bl/6J mice.Semantic proximity Read

The Prorenin Receptor: Multitasking Its Way Through Cardiovascular, Metabolic, and Renal DiseasesSemantic proximity Read

Dopamine regulation of Na+-K+-ATPase requires the PDZ-2 domain of sodium hydrogen regulatory factor-1 (NHERF-1) in opossum kidney cells.Semantic proximity Read

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor and NaCl transport mechanisms in the renal distal nephron.Semantic proximity Read

The renin phenotype: roles and regulation in the kidney.Semantic proximity Read

Identification of a receptor for extracellular renalase.Semantic proximity Read