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Functional genomics of the dopaminergic system in hypertension

17 Nov 2004

Abstract excerpt

Abnormalities in dopamine production and receptor function have been described in human essential hypertension and rodent models of genetic hypertension. Under normal conditions, D(1)-like receptors (D(1) and D(5)) inhibit sodium transport in the kidney and intestine. However, in the Dahl salt-sensitive and spontaneously hypertensive rats (SHRs) and in humans with essential hypertension, the D(1)-like...

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PMID: 15548830
DOI: 10.1152/physiolgenomics.00127.2004

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