Article
Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.
American journal of physiology. Renal physiology - 1 Jun 2018
Douma Lauren G, Holzworth Meaghan R, Solocinski Kristen, Masten Sarah H, Miller Amber H, Cheng Kit-Yan, Lynch I Jeanette, Cain Brian D, Wingo Charles S, Gumz Michelle L
Abstract excerpt
Many physiological functions have a circadian rhythm, including blood pressure (BP). BP is highest during the active phase, whereas during the rest period, BP dips 10-20%. Patients that do not experience this dip at night are termed "nondippers." Nondipping hypertension is associated with increased risk of cardiovascular disease. The mechanisms underlying nondipping hypertension are not understood. Without the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.