Article
An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Sept 2009
Zheng Xiangzhong, Koh Kyunghee, Sowcik Mallory, Smith Corinne J, Chen Dechun, Wu Mark N, Sehgal Amita
Abstract excerpt
The Drosophila PAR domain protein 1 (Pdp1) gene encodes a transcription factor with multiple functions. One isoform, PDP1epsilon, was proposed to be an essential activator of the core clock gene, Clock (Clk). However, a central clock function for PDP1epsilon was recently disputed, and genetic ana...
Topics
- Animals
- Animals, Genetically Modified
- Basic-Leucine Zipper Transcription Factors
- Circadian Rhythm
- Drosophila Proteins
- Drosophila melanogaster
- Male
- Motor Activity
- Mutation
- Protein Isoforms