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Article

An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Sept 2009

Zheng Xiangzhong, Koh Kyunghee, Sowcik Mallory, Smith Corinne J, Chen Dechun, Wu Mark N, Sehgal Amita

Abstract excerpt

The Drosophila PAR domain protein 1 (Pdp1) gene encodes a transcription factor with multiple functions. One isoform, PDP1epsilon, was proposed to be an essential activator of the core clock gene, Clock (Clk). However, a central clock function for PDP1epsilon was recently disputed, and genetic analysis has been difficult due to developmental lethality of Pdp1-null mutants. Here we report the discovery of a...

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Identifiers

PMID: 19726650
DOI: 10.1523/JNEUROSCI.2133-09.2009
PMCID: PMC2757269

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PDP1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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