Article
A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.
Science (New York, N.Y.) - 21 Sept 2001
Williams J A, Su H S, Bernards A, Field J, Sehgal A
Abstract excerpt
Output from the circadian clock controls rhythmic behavior through poorly understood mechanisms. In Drosophila, null mutations of the neurofibromatosis-1 (Nf1) gene produce abnormalities of circadian rhythms in locomotor activity. Mutant flies show normal oscillations of the clock genes period (per) and timeless (tim) and of their corresponding proteins, but altered oscillations and levels of a clock-controlled...
Topics
- Alleles
- Animals
- Biological Clocks
- Brain
- Calcium-Calmodulin-Dependent Protein Kinases
- Circadian Rhythm
- Cyclic AMP Response Element-Binding Protein
- Cyclic AMP-Dependent Protein Kinases
- Drosophila
- Drosophila Proteins