Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis.

doi:10.1242/dmm.010793

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Article

Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis.

Disease models & mechanisms - 1 May 2013

Mei Xue, Wu Shu, Bassuk Alexander G, Slusarski Diane C

Abstract excerpt

Epilepsy is a complex neurological disorder characterized by unprovoked seizures. The etiology is heterogeneous with both genetic and environmental causes. Genes that regulate neurotransmitters and ion channels in the central nervous system have been associated with epilepsy. However, a recent screening in human epilepsy patients identified mutations in the PRICKLE1 (PK1) locus, highlighting a potentially novel...

Topics

Adaptor Proteins, Signal Transducing
Animals
Dose-Response Relationship, Drug
Embryo, Nonmammalian
Epilepsy
Gene Knockdown Techniques
Humans
LIM Domain Proteins
Morpholinos
Mutation
Neurogenesis
Pentylenetetrazole
Retina
Swimming
Zebrafish
Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23324328
DOI: 10.1242/dmm.010793
PMCID: PMC3634651

Genes

PRICKLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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