Article
Self-nonself discrimination by T cells.
Science (New York, N.Y.) - 15 Jun 1990
von Boehmer H, Kisielow P
Abstract excerpt
The alpha beta T cell receptor (TCR) recognizes antigens that are presented by major histocompatibility complex (MHC)-encoded cell surface molecules by binding to both the antigen and the MHC molecules. Discrimination of self from nonself antigens and MHC molecules is achieved by negative and positive selection of T cells in the thymus: potentially harmful T cells with receptors that bind to self antigens plus...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Cell Survival
- Female
- H-2 Antigens
- Histocompatibility Antigens
- Immune Tolerance
- Killer Cells, Natural
- Male
- Mice
- Mice, Transgenic