Article
The enemy within: keeping self-reactive T cells at bay in the periphery.
Nature reviews. Immunology - 1 Jan 2002
Walker Lucy S K, Abbas Abul K
Abstract excerpt
The remarkable capacity of the mammalian immune system to coordinate deadly attacks against numerous invading pathogens, yet turn a blind eye to self-tissues continues to fascinate immunologists. It has been clear for some time that immune cells capable of recognizing self-proteins exist in normal individuals without seemingly causing harm. The 'peripheral tolerance' mechanisms that keep these cells in check are...
Topics
- Animals
- Apoptosis
- Autoantigens
- Autoimmunity
- Clonal Anergy
- Dendritic Cells
- Humans
- Infections
- Models, Immunological
- Phenotype
- Self Tolerance
- T-Lymphocytes