Selecting and maintaining a diverse T-cell repertoire.

Abstract excerpt

To provide a T-cell population that will respond promptly to foreign antigen, the immune system looks inward, using the variety of self-antigens to select and maintain a diverse repertoire of receptors. A protective immune system must include a T-lymphocyte population that is poised to respond to foreign antigenic peptides presented by self-major histocompatibility complex molecules. As the organism cannot...

Topics

• Animals
• Autoantigens
• Genetic Variation
• Homeostasis
• Humans
• Leukopoiesis
• Lymphatic System
• Major Histocompatibility Complex
• Receptors, Antigen, T-Cell
• Self Tolerance
• T-Lymphocyte Subsets
• T-Lymphocytes