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Article

HLA-DP variation as additional risk factor in IDDM.

Diabetes - 1 Jul 1990

Easteal S, Kohonen-Corish M R, Zimmet P, Serjeantson S W

Abstract excerpt

A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P less than 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium...

Topics

Diabetes Mellitus, Type 1
Genetic Variation
HLA-DP Antigens
HLA-DQ Antigens
HLA-DR Antigens
Haplotypes
Humans
Polymorphism, Restriction Fragment Length
Risk Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1972363
DOI: 10.2337/diab.39.7.855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1972363-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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HLA-DP variation as additional risk factor in IDDM.PMID 1972363Read ↗

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Heterogeneity of HLA genetic factors in IDDM susceptibility.Semantic proximity Read ↗

The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.Semantic proximity Read ↗

HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.Semantic proximity Read ↗

HLA associations in insulin-dependent diabetes mellitus: no independent association to particular DP genes.Semantic proximity Read ↗

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