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Article

HLA and IDDM: facts and speculations on the disease gene and its mode of inheritance.

Human immunology - 1 Apr 1991

Rubinstein P

Abstract excerpt

1. The mode of inheritance of the DR3- and DR4-associated susceptibility genotype is essentially recessive, based on both the segregation data and the existence of Hardy-Weinberg equilibrium in Ashkenazi Jewish and possibly in patients of other populations. 2. Maternal effects may alter the expressivity of IDDM in some susceptible offspring, depending on the maternal DR genotype. Thus, the number of susceptible...

Topics

Alleles
Diabetes Mellitus, Type 1
Gene Expression
Genetic Predisposition to Disease
Genotype
HLA Antigens
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR3 Antigen
HLA-DR4 Antigen
Humans

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Source

Identifiers

PMID: 2045289
DOI: 10.1016/0198-8859(91)90006-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2045289-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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