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Article

Mutant analysis of Cdt1's function in suppressing nascent strand elongation during DNA replication in Xenopus egg extracts.

Biochemical and biophysical research communications - 2 Sept 2017

Nakazaki Yuta, Tsuyama Takashi, Azuma Yutaro, Takahashi Mikiko, Tada Shusuke

Abstract excerpt

The initiation of DNA replication is strictly regulated by multiple mechanisms to ensure precise duplication of chromosomes. In higher eukaryotes, activity of the Cdt1 protein is temporally regulated during the cell cycle, and deregulation of Cdt1 induces DNA re-replication. In previous studies, we showed that excess Cdt1 inhibits DNA replication by suppressing progression of replication forks in Xenopus egg...

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Identifiers

PMID: 28694193
DOI: 10.1016/j.bbrc.2017.07.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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