Article

IL-21 signaling promotes the establishment of KSHV infection in human tonsil lymphocytes by increasing early targeting of plasma cells

2021-12-06

Abstract excerpt

Factors influencing Kaposi’s sarcoma-associated herpesvirus (KSHV) transmission and the early stages of KSHV infection in the human immune system remain poorly characterized. KSHV is known to extensively manipulate the host immune system and the cytokine milieu, and cytokines are known to influence the progression of KSHV-associated diseases. Here, using our unique model of KSHV infection in tonsil lymphocytes, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 126b470b-d8b5-537f-9b29-b41e21d3a511
DOI: 10.1101/2021.12.06.471359

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IL-21 signaling promotes the establishment of KSHV infection in human tonsil lymphocytes by increasing early targeting of plasma cellsDOI 10.1101/2021.12.06.471359Read

Unraveling the Kaposi Sarcoma-Associated Herpesvirus (KSHV) Lifecycle: An Overview of Latency, Lytic Replication, and KSHV-Associated DiseasesSemantic proximity Read

KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiationSemantic proximity Read

Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic InfectionSemantic proximity Read

Advances in KSHV Research: Molecular Pathogenesis, Immune Evasion, and Evolving Therapeutic HorizonSemantic proximity Read

Primary B Lymphocytes Infected with Kaposi's Sarcoma-Associated Herpesvirus Can Be Expanded In Vitro and Are Recognized by LANA-Specific CD4+ T Cells.Semantic proximity Read

Single-Cell Mass Cytometry Analysis of Human Tonsil T Cell Remodeling by Varicella Zoster VirusSemantic proximity Read

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.Semantic proximity Read

Interleukin-17 directly triggers Epstein-Barr virus lytic reactivation in latently infected human B cellsSemantic proximity Read

Kaposi’s Sarcoma-Associated Herpesvirus, the Etiological Agent of All Epidemiological Forms of Kaposi’s SarcomaSemantic proximity Read

Reactivation and Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus: An UpdateSemantic proximity Read

Potential anti-EBV effects associated with elevated interleukin-21 levels: a case report.Semantic proximity Read

A tonsil organoid model reveals Epstein-Barr virus infected germinal center B cell states during primary infectionSemantic proximity Read