Article
Nuclear DNA content and chromatin texture in multidrug-resistant human leukemic cell lines.
International journal of cancer - 3 Jan 1995
Dufer J, Millot-Broglio C, Oum'Hamed Z, Liautaud-Roger F, Joly P, Desplaces A, Jardillier J C
Abstract excerpt
Nuclear morphological alterations associated with multidrug resistance (MDR) were evaluated by image cytometry in various human leukemic cell sub-lines: 3 cell lines with P-gp-mediated resistance (CEM-VLB, HL60/Vinc, K562-Dox), the non-Pgp-mediated MDR HL60/AR leukemic cell line with over-expression of MRP, and the at-MDR CEM-VMI leukemic cell line with alteration of topoisomerase II. All these MDR cell sub-lines...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Analysis of Variance
- Animals
- Cell Nucleus
- Chromatin
- Cricetinae
- Cricetulus
- DNA, Neoplasm
- Drug Resistance, Multiple
- Drug Screening Assays, Antitumor