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Article

Involvement ofMDR1 P-glycoprotein in multifactorial resistance to methotrexate

1 Mar 1996

Abstract excerpt

Cellular resistance to methotrexate (MTX) is believed to be unaffected by expression of MDR1 P-glycoprotein (Pgp), a pleiotropic efflux pump acting on different hydrophobic compounds that enter cells by passive diffusion. A series of human leukemic CCRF-CEM sublines, isolated by multi-step selection for very high resistance to MTX, exhibit multiple mechanisms of MTX resistance, including decreased...

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PMID: 8598312
DOI: 10.1002/(sici)1097-0215(19960301)65:5<613::aid-ijc10>3.0.co;2-8

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