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Article

Selective binding interactions of deramciclane to the genetic variants of human alpha(1)-acid glycoprotein.

Biochimica et biophysica acta - 1 Mar 2010

Fitos Ilona, Visy Júlia, Simonyi Miklós, Mády György, Zsila Ferenc

Abstract excerpt

BACKGROUND: alpha(1)-Acid glycoprotein (AGP) plays a decisive role in the serum protein binding of several drugs.Genetic variants of AGP have different ligand binding properties. The binding of deramciclane (DER), a chiral anxiolytic agent, has been studied on A and F1/S genetic variants of AGP. METHODS: The effects of DER and reference drugs on the binding of specific fluorescent and circular dichroism (CD)...

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Identifiers

PMID: 19720112
DOI: 10.1016/j.bbagen.2009.08.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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