Article
Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.
The Journal of biological chemistry - 22 Apr 2011
Nishi Koji, Ono Tomomi, Nakamura Teruya, Fukunaga Naoko, Izumi Miyoko, Watanabe Hiroshi, Suenaga Ayaka, Maruyama Toru, Yamagata Yuriko, Curry Stephen, Otagiri Masaki
Abstract excerpt
Human α(1)-acid glycoprotein (hAGP) in serum functions as a carrier of basic drugs. In most individuals, hAGP exists as a mixture of two genetic variants, the F1*S and A variants, which bind drugs with different selectivities. We prepared a mutant of the A variant, C149R, and showed that its drug-binding properties were indistinguishable from those of the wild type. In this study, we determined the crystal...
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