Article
Ligand specificity of the genetic variants of human alpha1-acid glycoprotein: generation of a three-dimensional quantitative structure-activity relationship model for drug binding to the A variant.
Molecular pharmacology - 1 Jul 1998
Hervé F, Caron G, Duché J C, Gaillard P, Abd Rahman N, Tsantili-Kakoulidou A, Carrupt P A, d'Athis P, Tillement J P, Testa B
Abstract excerpt
Human alpha1-acid glycoprotein (AAG) is a mixture of at least two genetic variants: the A variant and the F1 and/or S variant or variants, which are encoded by two different genes. In a continuation of previous studies indicating specific drug transport roles for each AAG variant according to its separate genetic origin, this work was designed to (1) determine the affinities of the two main gene products of AAG...
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