Article
Ligand specificity of the genetic variants of human alpha1-acid glycoprotein: generation of a three-dimensional quantitative structure-activity relationship model for drug binding to the A variant.
Molecular pharmacology - 1 Jul 1998
Hervé F, Caron G, Duché J C, Gaillard P, Abd Rahman N, Tsantili-Kakoulidou A, Carrupt P A, d'Athis P, Tillement J P, Testa B
Abstract excerpt
Human alpha1-acid glycoprotein (AAG) is a mixture of at least two genetic variants: the A variant and the F1 and/or S variant or variants, which are encoded by two different genes. In a continuation of previous studies indicating specific drug transport roles for each AAG variant according to its...
Topics
- Alleles
- Binding, Competitive
- Humans
- Ligands
- Models, Molecular
- Orosomucoid
- Structure-Activity Relationship
- Substrate Specificity