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Article

Conformation selectivity in the binding of diazepam and analogues to alpha1-acid glycoprotein.

Bioorganic & medicinal chemistry - 15 Jul 2007

Fitos Ilona, Visy Júlia, Zsila Ferenc, Mády György, Simonyi Miklós

Abstract excerpt

Diazepam, a 1,4-benzodiazepine lacking chiral centre, exists in an equimolar mixture of two chiral conformers. Induced circular dichroism spectra for the binding of diazepam and its 3,3-dimethyl substituted analogues to alpha1-acid glycoprotein (AGP) revealed that opposite to human serum albumin, AGP preferably binds the P-conformers. Accordingly, slightly favoured binding of (R)-enantiomers of 3-alkyl...

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Identifiers

PMID: 17507228
DOI: 10.1016/j.bmc.2007.04.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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