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Article

Selective binding of coumarin enantiomers to human alpha1-acid glycoprotein genetic variants.

Bioorganic & medicinal chemistry - 15 Mar 2006

Hazai Eszter, Visy Júlia, Fitos Ilona, Bikádi Zsolt, Simonyi Miklós

Abstract excerpt

Coumarin-type anticoagulants, warfarin, phenprocoumon and acenocoumarol, were tested for their stereoselective binding to the human orosomucoid (ORM; AGP) genetic variants ORM 1 and ORM 2. Direct binding studies with racemic ligands were carried out by the ultrafiltration method; the concentrations of free enantiomers were determined by capillary electrophoresis. The binding of pure enantiomers was investigated...

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Identifiers

PMID: 16290938
DOI: 10.1016/j.bmc.2005.10.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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