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Article

Specific ligand binding on genetic variants of human alpha1-acid glycoprotein studied by circular dichroism spectroscopy.

Biochemical pharmacology - 15 Feb 2004

Fitos Ilona, Visy Júlia, Zsila Ferenc, Bikádi Zsolt, Mády György, Simonyi Miklós

Abstract excerpt

Human alpha1-acid glycoprotein displays genetic polymorphism. Different drug binding properties of the two main genetic products (F1-S and A variants) have been demonstrated. In search for specific circular dichroism (CD) probes, dicumarol and acridine orange were found to specifically bind to the F1-S and A variants, respectively. Dicumarol binding to the F1-S variant produced induced Cotton effects originating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14757167
DOI: 10.1016/j.bcp.2003.09.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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