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Article

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

Nature genetics - 25 Dec 2011

Nikolaev Sergey I, Rimoldi Donata, Iseli Christian, Valsesia Armand, Robyr Daniel, Gehrig Corinne, Harshman Keith, Guipponi Michel, Bukach Olesya, Zoete Vincent, Michielin Olivier, Muehlethaler Katja, Speiser Daniel, Beckmann Jacques S, Xenarios Ioannis, Halazonetis Thanos D, Jongeneel C Victor, Stevenson Brian J, Antonarakis Stylianos E

Abstract excerpt

We performed exome sequencing to detect somatic mutations in protein-coding regions in seven melanoma cell lines and donor-matched germline cells. All melanoma samples had high numbers of somatic mutations, which showed the hallmark of UV-induced DNA repair. Such a hallmark was absent in tumor sa...

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Identifiers

PMID: 22197931
DOI: 10.1038/ng.1026

Genes

BRAF
DSC1
FAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22197931-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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