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Characterization of DNA variants in the human kinome in breast cancer.

Scientific reports - 30 Sept 2015

Agarwal Divyansh, Qi Yuan, Jiang Tingting, Liu Xiuping, Shi Weiwei, Wali Vikram B, Turk Benjamin, Ross Jeffrey S, Fraser Symmans W, Pusztai Lajos, Hatzis Christos

Abstract excerpt

Kinases play a key role in cancer biology, and serve as potential clinically useful targets for designing cancer therapies. We examined nucleic acid variations in the human kinome and several known cancer-related genes in breast cancer. DNA was extracted from fine needle biopsies of 73 primary breast cancers and 19 metastatic lesions. Targeted sequencing of 518 kinases and 68 additional cancer related genes was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26420498
DOI: 10.1038/srep14736
PMCID: PMC4588561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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