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Article

Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma.

Pigment cell & melanoma research - 1 Jul 2014

Jeck William R, Parker Joel, Carson Craig C, Shields Janiel M, Sambade Maria J, Peters Eldon C, Burd Christin E, Thomas Nancy E, Chiang Derek Y, Liu Wenjin, Eberhard David A, Ollila David, Grilley-Olson Juneko, Moschos Stergios, Neil Hayes D, Sharpless Norman E

Abstract excerpt

Somatic sequencing of cancers has produced new insight into tumorigenesis, tumor heterogeneity, and disease progression, but the vast majority of genetic events identified are of indeterminate clinical significance. Here, we describe a NextGen sequencing approach to fully analyzing 248 genes, inc...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24628946
DOI: 10.1111/pcmr.12238
PMCID: PMC4121659

Genes

BRAF
ERBB4
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24628946-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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