Article
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.
Nature genetics - 25 Dec 2011
Stark Mitchell S, Woods Susan L, Gartside Michael G, Bonazzi Vanessa F, Dutton-Regester Ken, Aoude Lauren G, Chow Donald, Sereduk Chris, Niemi Natalie M, Tang Nanyun, Ellis Jonathan J, Reid Jeffrey, Zismann Victoria, Tyagi Sonika, Muzny Donna, Newsham Irene, Wu YuanQing, Palmer Jane M, Pollak Thomas, Youngkin David, Brooks Bradford R, Lanagan Catherine, Schmidt Christopher W, Kobe Bostjan, MacKeigan Jeffrey P, Yin Hongwei, Brown Kevin M, Gibbs Richard, Trent Jeffrey, Hayward Nicholas K
Abstract excerpt
We sequenced eight melanoma exomes to identify new somatic mutations in metastatic melanoma. Focusing on the mitogen-activated protein (MAP) kinase kinase kinase (MAP3K) family, we found that 24% of melanoma cell lines have mutations in the protein-coding regions of either MAP3K5 or MAP3K9. Structural modeling predicted that mutations in the kinase domain may affect the activity and regulation of these protein...
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