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Article

Polymorphism of the human complement component C4.

Experimental and clinical immunogenetics - 1 Jan 1990

Campbell R D, Dunham I, Kendall E, Sargent C A

Abstract excerpt

The genes encoding the two C4 isotypes, C4A and C4B, lie 10 kb apart in the class III region of the human major histocompatibility complex. The two isotypes exhibit extensive structural polymorphism. Characterisation of a number of C4A and C4B alleles has established the pattern of polymorphism in C4 and this has provided a structural basis for the observed functional and serological differences between the C4...

Topics

Alleles
Amino Acid Sequence
Chromosomes, Human, Pair 6
Complement C4
Complement C4a
Complement C4b
Electrophoresis
Haplotypes
Humans
Major Histocompatibility Complex
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Structure

Peptide Fragments

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1971760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1971760-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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