Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics of human complement component C4 and evolution the central MHC.

Frontiers in bioscience : a journal and virtual library - 1 Aug 2001

Martinez O P, Longman-Jacobsen N, Davies R, Chung E K, Yang Y, Gaudieri S, Dawkins R L, Yu C Y

Abstract excerpt

The two classes of human complement component C4 proteins C4A and C4B manifest differential chemical reactivities and binding affinities towards target surfaces and complement receptor CR1. There are multiple, polymorphic allotypes of C4A and C4B proteins. A complex multiplication pattern of C4A and C4B genes with variations in gene size, gene dosage and flanking genes exists in the population. This is probably...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Complement C4

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Complement System Proteins

Share to Evolution, Molecular

Share to Major Histocompatibility Complex

Share to Phylogeny

Share to Sequence Homology, Amino Acid

Share to Terminology as Topic

Source

Identifiers

PMID: 11487475
DOI: 10.2741/martinez

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics of human complement component C4 and evolution the central MHC.PMID 11487475Read ↗

Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.Semantic proximity Read ↗

Molecular genetics of the human MHC complement gene cluster.Semantic proximity Read ↗

Complement genetics, deficiencies, and disease associationsSemantic proximity Read ↗

The Evolution and Appearance of C3 Duplications in Fish Originate an Exclusive Teleost c3 Gene Form with Anti-Inflammatory ActivitySemantic proximity Read ↗

Specific Evolution and Gene Family Expansion of Complement 3 and Regulatory Factor H in FishSemantic proximity Read ↗

Complement regulators in human disease: lessons from modern genetics.Semantic proximity Read ↗

Complement C3 and its polymorphism: biological and clinical consequences.Semantic proximity Read ↗

Revised nomenclature for human complement component C4. WHO-IUIS Nomenclature Sub-Committee.Semantic proximity Read ↗

Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases.Semantic proximity Read ↗

Structures of complement component C3 provide insights into the function and evolution of immunitySemantic proximity Read ↗

The human factor H protein family – an updateSemantic proximity Read ↗

Polymorphism of the complement components in human pathology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.