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Article

Null alleles of human complement C4. Evidence for pseudogenes at the C4A locus and for gene conversion at the C4B locus.

The Journal of experimental medicine - 1 Jan 1990

Braun L, Schneider P M, Giles C M, Bertrams J, Rittner C

Abstract excerpt

The two genes for the C4A and C4B isotypes of the fourth component of human complement are located in the MHC class III region. Previous studies have demonstrated the unusual expression of C4 genes in the form of aberrant or duplicated haplotypes. Null alleles of C4A or C4B (AQ0 or BQ0) have been defined by the absence of gene products and occur at frequencies of 0.1-0.3. However, only some C4 null alleles are...

Topics

Alleles
Base Sequence
Complement C4
Complement C4a
Complement C4b
DNA
DNA Probes
Gene Conversion
Genes
Homozygote
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Polymerase Chain Reaction

Pseudogenes

Source

Open in PubMed Open full text

Identifiers

PMID: 2295875
DOI: 10.1084/jem.171.1.129
PMCID: PMC2187646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2295875-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Null alleles of human complement C4. Evidence for pseudogenes at the C4A locus and for gene conversion at the C4B locus.PMID 2295875Read ↗

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